Hormone Replacement Therapy Is Associated with Less Coronary Atherosclerosis in Postmenopausal Women

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Postmenopausal hormone therapy is associated with atherosclerosis progression in women with abnormal glucose tolerance.

BACKGROUND Abnormal glucose tolerance (AGT; diabetes or impaired glucose tolerance) is associated with increased risk of cardiovascular disease, especially in women. Cardiovascular disease rates in women increase after menopause. The Women's Health Initiative found that postmenopausal hormone therapy (PHT) increased the risk of cardiovascular disease and that effects in diabetic women did not d...

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Postmenopausal hormone replacement therapy.

Several comprehensive accounts of postmenopausal hormone replacement treatment have been published in the United Kingdom in the past year`so in this review we concentrate on areas which, while often controversial, are of concern to the practising physician. We discuss the effects of postmenopausal hormone replacement therapy on the risks of developing coronary heart disease, osteoporosis, and c...

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Serum vitamin A status in women users of lowdose oral contraceptives and in postmenopausal women taking hormone replacement therapy.

Background: One of the most important nonenzymatic antioxidant defense systems is vitamin A, and is considered as an important dietary agent for reducing cardiovascular diseases. Objective: The objective of this study was to investigate the serum vitamin A status in women who used low-dose oral contraceptives (OCs) containing 0.15 mg levonorgestrol and 0.03 mg ethinyl estradiol and also in...

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Hormone replacement therapy and atherosclerosis in postmenopausal women: does aging limit therapeutic benefits?

Despite the clear-cut epidemiological evidence of protective effects of endogenous estrogens in premenopausal women,1,2 the results of randomized clinical trials using conjugated equine estrogens and medroxyprogesterone acetate instead of natural hormones have led to a paradigm shift in the usefulness of hormone treatment in postmenopausal women.3,4 One of the main criticisms in addition to the...

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Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atherosclerosis in postmenopausal women: a randomized controlled trial.

CONTEXT Hormone replacement therapy (HRT) and antioxidant vitamins are widely used for secondary prevention in postmenopausal women with coronary disease, but no clinical trials have demonstrated benefit to support their use. OBJECTIVE To determine whether HRT or antioxidant vitamin supplements, alone or in combination, influence the progression of coronary artery disease in postmenopausal wo...

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ژورنال

عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism

سال: 2003

ISSN: 0021-972X,1945-7197

DOI: 10.1210/jc.2003-031008